Hewlett Packard Enterprise has been selected to participate in multiple research and development projects as part of the first phase of the U.S. Department of Energy’s Genesis Mission, a national initiative designed to accelerate artificial intelligence and scientific discovery.
The projects will see HPE contribute expertise across AI model development, high-performance computing, networking, cybersecurity, weather forecasting, fusion energy and water availability research.
The announcement builds on HPE’s long-standing collaboration with the Department of Energy and its national laboratories, where the company has helped develop some of the world’s most advanced supercomputing and AI systems.
Supporting the Next Generation of Scientific AI
The Genesis Mission aims to create an integrated platform that combines artificial intelligence, supercomputing, quantum technologies and advanced scientific instruments to speed scientific breakthroughs and strengthen U.S. research capabilities.
As part of the initiative, HPE is delivering advanced computing systems, including the upcoming Lux platform, which is expected to become the first AI system dedicated to scientific research for the Genesis Mission.
Lux is being developed in partnership with AMD and Oak Ridge National Laboratory.
AI Research Spans Multiple Scientific Fields
HPE has been invited to participate in several research projects covering a broad range of scientific and engineering challenges.
Among them is an agentic AI system designed to support fusion energy experiments by combining reinforcement learning with physics-based foundation models.
Additional projects include AI-driven networking for future 6G swarm robotics, autonomous network operations for scientific computing environments, improved long-term weather forecasting, distributed scientific workflow optimization and AI-powered cybersecurity designed to detect threats targeting scientific data.
The research is intended to determine how AI can improve experimentation, accelerate discovery and enhance predictive capabilities across national research programs.
Expanding a Longstanding Government Partnership
HPE has collaborated with the Department of Energy and national laboratories for decades, contributing to high-performance computing systems that support scientific research and national security.
Its expanded role in the Genesis Mission reflects growing demand for infrastructure capable of supporting increasingly complex AI workloads while integrating traditional supercomputing and emerging technologies.
The company said its work will help establish the foundation for future large-scale AI research initiatives.
AI Infrastructure Becomes National Priority
Government agencies, research institutions and technology companies are investing heavily in AI infrastructure as nations compete to advance scientific discovery and maintain technological leadership.
Programs like the Genesis Mission are designed to bring together public and private organizations to develop AI systems capable of addressing challenges ranging from energy production and cybersecurity to climate science and advanced manufacturing.
For HPE, participation expands its role as a technology provider supporting large-scale scientific computing and sovereign AI initiatives.
The Bottom Line
Artificial intelligence is becoming an essential tool for scientific research, and the U.S. Department of Energy’s Genesis Mission represents one of the nation’s most ambitious efforts to combine AI, supercomputing and advanced science. HPE’s participation reinforces its position as a key technology partner in building the infrastructure that could drive the next generation of scientific and engineering breakthroughs.